The Master Manipulator

The Master Manipulator is the Human artifact, gifted to them by the Cultivator in hopes that they may one day unite with the other races and use the artifacts to unseal the Monolith Gate and defeat The Ruin.

The Master Manipulator appears to be an ancient Matter Manipulator, though its design is rounder and with a colour scheme that better matches other ancient items. As Esther describes it as "the original", it's likely that the artifact was reverse-engineered to create the Terrene Protectorate's Matter Manipulator. This connection is supported by the artifact being in the possession of the former Grand Protector Esther Bright, though the reason for her still having it after leaving Earth is left seemingly unexplained. There was once a cut line of dialogue from a Nightly Build of the game however which indicated that it was gifted to her by Leda Portia, so this is potentially (if not likely) still the case.